The road was partially blocked near Lympstone on Friday morning (October 9) after a crash on the A376 route to Exmouth.
Traffic was reported to be queuing and slow for around two hours after the crash, near the Saddlers, at Lympstone.
Police said there were minor injuries and Highways attended to clear up spilled fuel from the road.
The road was reopened in both directions by 11am.
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